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Mission

We work towards understanding the mechanisms of cellular reprogramming that governs the transformation of a somatic cell into a pluripotent one. We identify regulatory genes and gene products that govern the state of pluripotency. We use this knowledge to generate human isogenic pluripotent stem cells and to improve the efficiency of somatic cell nuclear transfer.
Recommended Reading
Induced pluripotent stem cell lines derived from human somatic cells. Yu, et al

Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Takahashi, et al

Early and delayed aspects of nuclear reprogramming during cloning. Latham

Gene Expression Profiling of Embryonic Stem Cells Leads to Greater Understanding of Pluripotency and Early Developmental Events. Rao and Stice

Birth of parthenogenetic mice that can develop to adulthood. T Kono, et al

Derivation of embryonic germ cells and male gametes from embryonic stem cells. N Geijsen, et al

Nuclei of adult mammalian somatic cells are directly reprogrammed to oct-4 stem cell gene expression by amphibian oocytes. Byrne, et al

Epigenetic reprogramming in early mammalian development and following somatic nuclear transfer. Dean, et al

Somatic cell nuclear transfer. Wilmut, et al

A molecular programme for the specification of germ cell fate in mice. Saitou, et al

"Stemness": transcriptional profiling of embryonic and adult stem cells. Ramalho-Santos

Oct-4: gatekeeper in the beginnings of mammalian development. Pesce and Scholer

Genetic Reprogramming following Nuclear Transfer in Amphibia. Gurdon

Direct cell reprogramming is a stochastic process amenable to acceleration. Hanna, et al

Systems biology of stem cell fate and cellular reprogramming. Macarthur, et al

Induction of human neuronal cells by defined transcription factors. Pang, et al

Plasticity and Reprogramming of Differentiated Cells in Amphibian Regeneration. Brockes and Kumar

 

A Precarious Balance: Pluripotency Factors as Lineage Specifiers. Loh and Lim