We work towards understanding the mechanisms of cellular reprogramming that governs the transformation of a somatic cell into a pluripotent one. We identify regulatory genes and gene products that govern the state of pluripotency. We use this knowledge to generate human isogenic pluripotent stem cells and to improve the efficiency of somatic cell nuclear transfer.
Bradly Alicea
Research Associate (July 2009 - Present)
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Bradly joined the laboratory in 2009, and since joining has worked on 1) understanding complex relationships between the translatome and transcriptome, 2) the discrete dynamical modeling of cell populations undergoing reprogramming, and 3) the application of systems biology-oriented measurement/analytical techniques to wide range of cell types, including those with pluripotent and neuronal characteristics.
Bradly Alicea