We work towards understanding the mechanisms of cellular reprogramming that governs the transformation of a somatic cell into a pluripotent one. We identify regulatory genes and gene products that govern the state of pluripotency. We use this knowledge to generate human isogenic pluripotent stem cells and to improve the efficiency of somatic cell nuclear transfer.
To Reach Us
Cellular Reprogramming Laboratory
Department of Animal Science B270 Anthony Hall Michigan State University East Lansing, MI 48824
Nuclear Transfer-Cloning can reprogram the nucleus of somatic cells to the extreme of bypassing the complex biological processes of gametogenesis and fertilization. Embryos thus reengineered can develop into live offspring ....(more)
Research
STEM CELLS
Embryonic Stem (ES) Cells are isolated from a preimplantation embryo at approximately 5 or 7 days after fertilization (human and Monkey respectively) By definition ES cells must be able to fulfill three characteristics ....(more)
Production of recombinant albumin by a herd of cloned transgenic cattle Echelard Y, Williams JL, Destrempes MM, Koster JA, Overton SA, Pollock DP, Rapiejko KT, Behboodi E, Masiello NC, Gavin WG, Pommer J, Van Patten SM, Faber DC, Cibelli JB, Meade HM. Transgenic Res. 2008 Jun;18(3):361-76.
Cloned Cattle Can Be Healthy and Normal Lanza RP, Cibelli JB, Faber D, Sweeney RW, Henderson B, Nevala W, West MD, Wettstein PJ Science 2001 Nov 30;294(5548):1893-4
The health profile of cloned animals Cibelli JB, Campbell KH, Seidel GE, West MD, Lanza RP Nat Biotechnol 2002 Jan;20(1):13-4
The ethical validity of using nuclear transfer in human transplantation Lanza RP, Caplan AL, Silver LM, Cibelli JB, West MD, Green RM. JAMA 2000 Dec 27;284(24):3175-9
Prospects for the use of nuclear transfer in human transplantation Lanza RP, Cibelli JB, West MD Nature Biotechnology 1999 Dec;17(12):1171-4
Human Therapeutic Cloning Lanza RP, Cibelli JB, West MD Nature Medicine September 1999.
Cloning cattle in 1998: present and future opportunities Stice SL and Cibelli JB Proceeding for American Embryo Transfer Association. San Antonio Texas. October 1998.
New developments in nuclear transfer technology Stice SL and Cibelli JB Proceedings of the Annual Meeting Canadian Society of Animal Sciences. July 1998.
Somatic cell nuclear transplantation in cattle. The Cloning symposium: Reprogramming cell fate-transgenesis and cloning Robl JM, Cibelli JB, Stice SL The Institute of Reproduction and Development. Melbourne, Australia. April 1998.
Cloning: new breakthroughs leading to commercial opportunities Stice SL, Robl JM, Ponce de León FA, Jerry J., Golueke PG, Cibelli JB, Kaine JJ Theriogenology 49:129-138. 1998.
Letters & Popular Science
Letters
To the Honorable George W. Bush, President of the United States The Washington Post February 21, 2000
