Mission

We work towards understanding the mechanisms of cellular reprogramming that governs the transformation of a somatic cell into a pluripotent one. We identify regulatory genes and gene products that govern the state of pluripotency. We use this knowledge to generate human isogenic pluripotent stem cells and to improve the efficiency of somatic cell nuclear transfer.
Original Reports

Polycomb gene expression and histone H3 lysine 27 trimethylation changes during bovine preimplantation development.

Ross PJ, Ragina NP, Rodriguez RM, Iager AE, Siripattarapravat K, Lopez-Corrales N, Cibelli JB.
Reproduction. 2008 Dec;136(6):777-85.

 

Trichostatin A Improves Histone Acetylation in Bovine Somatic Cell Nuclear Transfer Early Embryos.

Iager AE, Ragina NP, Ross PJ, Beyhan Z, Cunniff K, Rodriguez RM, Cibelli JB.      
Cloning Stem Cells. 2008 Sep;10(3):371-9.

 

Parthenogenetic activation of bovine oocytes using bovine and murine phospholipase C zeta

Ross PJ, Beyhan Z, Iager AE, Yoon SY, Malcuit C, Schellander K, Fissore RA, Cibelli JB.             
BMC Dev Biol. 2008 Feb 19;8:16.

 

Development. Is therapeutic cloning dead?
Cibelli JB
Science 2007 Dec 21;318(5858):1879-80

Human parthenogenetic blastocysts derived from noninseminated cryopreserved human oocytes
Polak de Fried E, Ross PJ, Zang G, Divita A, Cunniff K, Denaday F, Salamone D, Kiessling A, Cibelli J
Fertil Steril. 2007 Aug 11 [Epub ahead of print]

Developmental Biology. A decade of cloning mystique
Cibelli JB Science, 2007 May 18;316(5827):990-2

Transcriptional reprogramming of somatic cell nuclei during preimplantation development of cloned bovine embryos
Beyhan Z, Ross JP, Iager AE, Kocabas AM, Rosa GJ, Cibelli JB Dev Biol, 2007 May 15;305(2):637-49. Epub 2007 Feb 7

Oocyte spontaneous activation in different rat strains
Ross JP, Yabuuchi A, Cibelli JB Cloning Stem Cells, 2006 Winter;8(4):275-82

Full developmental potential of mammalian preimplantation embryos is maintained after imaging using a spinning-disk confocal microscope
Ross JP, Perez GI, Ko T, Yoo MS, Cibelli JB Biotechniques, 2006 Dec;41(6):741-50

The Transcriptome of Human Oocytes
(Click Here to Access the SUPPLEMENTARY DATA SET)
Kocabas AM, Crosby J, Ross PJ, Otu HH, Beyhan Z, Can H, Tam WL, Rosa GJM, Halgren RG, Lim B, Fernandez E, Cibelli JB
PNAS, September 19, 2006. 103 (38):14027-14032

Effect of timing of the removal of oocyte chromosomes before or after injection of somatic nucleus on development of NT embryos.
Wakayama S, Cibelli JB, Wakayama T
Cloning Stem Cells. 2003;5(3):

Nonhuman primate parthenogenetic stem cells
Vrana KE, Hipp J, Goss A, McCool BA, Riddle DR, Walker SJ, Wettstein PJ, Studer LP, Tabar V, Cunniff K, Chapman K, Vilner L, West MD, Grant KA, and Cibelli JB
PNAS, September 22, 2003

Parthenogenetic stem cells in non-human primates
Cibelli JB, Vrana K, Chapman K, Cunniff K, Worst T, Green H, Walker S, Gutin P, Vilner L, Tabar V, Dominko T, Kane J, Wettstein P, Suder L, West MD & Grant K
Science, February 1st 2002.

Somatic Cell Nuclear Transfer in Humans: Pronuclear and Early Embryonic Development
Cibelli JB, Kiessling A, Cunniff K, Richards C, Lanza RP, West MD
e-biomed: The Journal of Regenerative Medicine, Volume 2, 2001, November 26,2001

Cloned Cattle Can Be Healthy and Normal
Lanza RP, Cibelli JB, Faber D, Sweeney RW, Henderson B, Nevala W, West MD, Wettstein PJ
Science 2001 Nov 30;294(5548):1893-4

Placental Abnormalities in a Viable Cloned Calf
Hill JR , Edwards JF, Sawyer N, Blackwell C, and Cibelli JB
Cloning, Vol 3, Number 2, 2001

Cloning of an Endangered Species (Bos guarus) Using Interspecies Nuclear Transfer
Lanza RL, Cibelli JB, Diaz F, Moraes CT, Farin PW, Farin EF, Hammer CJ, West MD, Damiani P
Cloning, Vol 2, Number 2, 2000

Extension of cell life-span and telomere length in animals cloned from senescent somatic cells
Lanza RP, Cibelli JB, Blackwell C, Cristofalo VJ, Francis MK, Baerlocher GM, Mak J, Schertzer M, Chavez EA, Sawyer N, Lansdorp PM, West MD
Science 2000 Apr 28;288(5466):665-9

Clinical and Pathological Features of Cloned Transgenic Calves and Fetuses: (13 case study)
Hill JR, Roussel AJ, Cibelli JB, Edwards JF, Hooper NL, Miller MW, Thompson JA, Looney CR, Westhusin ME, Robl JM, Stice SL
Theriogenology 51:1451-1465, 1999.

Cloned Transgenic Calves Produced from Non-quiescent Fetal Fibroblasts
Cibelli JB, Stice SL, Golueke PJ, Kane J, Jerry J, Blackwell C, F. Ponce de León A. & Robl JM
Science vol.280:1256-1258. 1998.

Transgenic Bovine Chimeric Offspring Produced from Somatic Cell-derived Stem-Like Cells
Cibelli, JB, Stice SL, Golueke PJ, Kane J, Jerry J, Blackwell C, F. Ponce de León A. & Robl JM
Nature Biotechnology vol.16; 642-646. 1998.

Somatic cell cloned transgenic bovine neurons for transplantation in parkinsonian rats
Zawada WM(*), Cibelli JB(*), Choi PK, Clarkson ED, Golueke PJ, Witta SE, Bell KP, Kane J, Ponce de León A., Jerry DJ, Robl JM, Freed CR & Stice SL
(*) equal contribution.
Nature Medicine vol.4:569-574. 1998

Evaluation of developmental competence, nuclear and ooplasmic maturation of calf oocytes
Damiani P, Fissore RA, Cibelli JB, Robl J.M. & Duby RT
Molecular Reproduction & Development 45:521-534. 1996.

Comparison of two semen extraction routines in bovines with artificial vagina
Cibelli JB, Allende RA & Andreozzi RA
CABIA, year 6, n'23. 1991.

 
Reviews

Interspecies nuclear transfer: implications for embryonic stem cell biology

Beyhan Z, Iager AE, Cibelli JB.
Cell Stem Cell. 2007 Nov;1(5):502-12. Review


Risk assessment of meat and milk from cloned animals

Yang X, Tian XC, Kubota C, Page R, Xu J, Cibelli J, Seidel G Jr
Nature Biotechnol, 2007 Jan;25(1):77-83

Sperm mediated transgenesis rushes 'Back to the Future'.

Cibelli JB
Mol Ther. 2002 Dec;6(6):699-700.

The health profile of cloned animals.

Cibelli JB, Campbell KH, Seidel GE, West MD, Lanza RP
Nat Biotechnol 2002 Jan;20(1):13-4

The ethical validity of using nuclear transfer in human transplantation.

Lanza RP, Caplan AL, Silver LM, Cibelli JB, West MD, Green RM.
JAMA 2000 Dec 27;284(24):3175-9

Prospects for the use of nuclear transfer in human transplantation

Lanza RP, Cibelli JB, West MD
Nature Biotechnology 1999 Dec;17(12):1171-4

Human Therapeutic Cloning

Lanza RP, Cibelli JB, West MD
Nature Medicine September 1999.

Cloning cattle in 1998: present and future opportunities

Stice SL and Cibelli JB
Proceeding for American Embryo Transfer Association. San Antonio Texas. October 1998.

New developments in nuclear transfer technology

Stice SL and Cibelli JB
Proceedings of the Annual Meeting Canadian Society of Animal Sciences. July 1998.

Somatic cell nuclear transplantation in cattle. The Cloning symposium: Reprogramming cell fate-transgenesis and cloning

Robl JM, Cibelli JB, Stice SL
The Institute of Reproduction and Development. Melbourne, Australia. April 1998.

Cloning: new breakthroughs leading to commercial opportunities

Stice SL, Robl JM, Ponce de León FA, Jerry J., Golueke PG, Cibelli JB, Kaine JJ
Theriogenology 49:129-138. 1998.

 
Letters & Popular Science

Letters

To the Honorable George W. Bush, President of the United States
The Washington Post
February 21st 2000
          
Science over Politics
Science, Vol. 283
March 1999

Popular Science

The First Human Cloned Embryo
Cibelli JB, Lanza RP, West M.D
Scientific American January 2002

 
Books & Book Chapters

Books

“Principles of Cloning”
Jose Cibelli, Editor
Academic Press, 2002

Book Chapters

Embryonic stem cells from parthenotes

Cibelli JB, Cunniff K, Vrana KE
Methods Enzymol. 2006;418:117-35.
           

Human Therapeutic Cloning

Cibelli JB
The Humana Press, 2002
 

A Historical Perspective of Nuclear Transfer Cloning

Teskin R, Cibelli JB
CABI Publishing, New York 2002