Nuclear Transfer-Cloning can reprogram the nucleus of somatic cells to the extreme of bypassing the complex biological processes of gametogenesis and fertilization. Embryos thus reengineered can develop into live offspring ....(more)
Embryonic Stem (ES) Cells are isolated from a preimplantation embryo at approximately 5 or 7 days after fertilization (human and Monkey respectively) By definition ES cells must be able to fulfill three characteristics ....(more)
Cellular Reprogramming Laboratory: Understanding Nuclear Transfer and Stem Cells
Mission: We work towards understanding the mechanisms of cellular reprogramming that governs the transformation of a somatic cell into a pluripotent one. We identify regulatory genes and gene products that govern the state of pluripotency. We use this knowledge to generate human isogenic pluripotent stem cells and to improve the efficiency of somatic cell nuclear transfer.